Pyrazine is a six-member heterocyclic compound containing two nitrogen atoms, located at one-fourth position. A pyrazine and its derivatives are most commonly used as a pharmaceutical, food colouring agent and as a corrosion inhibitor. It has chemistry and chemical characteristics due to nitrogen atoms present which can be obtained from both naturally and synthetically. A pyrazine and its derivatives are used effectively in corrosion media to prevent metal and metal alloy from corrosion. Chemical and electrochemical methods are commonly used as corrosion monitoring techniques, in which weight loss EIS and PDP are prominent. Their mixed type of nature has been reported in previously published works. There have also been works on the use of computation calculation in recent works, which include DFT calculation and MD Simulation are the main ones. The future research related to the pyrazine has also been highlighted.