The evaluation of the lipid spectrum of the blood plasma and immunocyte membranes is important for timely diagnostic and correction of pathological changes revealed at the cytochemical level. The identification of lipid fractions using high-performance liquid chromatography (HPLC) allows for separate detection of minor fractions of lysophospholipids (lysophosphatidylcholine and lysophosphatidylethanolamine). The study was performed using a photometric sensor and reverse-phase column C18. The following fractions were obtained: lysophosphatidylcholine, lysophosphatidylethanolamine, sphingomyelin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, and phosphatidylserine. The ratio of these fractions is a sensitive marker of pathological shifts in the lipid spectrum both in the blood plasma and immunocyte membranes

Until recently, bedaquiline and linezolid were relatively unavailable in antituberculosis dispensaries. Patients that needed these drugs were directed to specialized Federal antituberculosis institutions. The study was aimed to evaluate remote results of the treatment of patients with drug-resistant pulmonary tuberculosis who had previous ineffective therapy at a local antituberculosis dispensary and directed to specialized Federal antituberculosis institutions. A total of 143 patients of both sexes aged 20-60 years old were examined. These patients received therapy at the Tver Regional Clinical Antituberculosis Dispensary in 2010-2014. To increase adherence to the treatment, a complex of measures were taken that included an individual session with a specialist, organization of communication with other patients that received effective therapy for tuberculosis, and watching of an educational video. A complex of measures on an increase in the adherence to the treatment among patients with pulmonary tuberculosis provided positive results in 143 patients. These patients agreed to possible surgical intervention in the Federal Antituberculosis Institution. After the surgical treatment, cavity closure and/or abacillation were registered in 132 patients. Adherence to the consumption of antituberculosis drugs significantly increased in the studied patients.