Summary High-temperature (HT) deep carbonate reservoirs are typically drilled using barite (BaSO4) as a weighting material. Primary production in these tight reservoirs comes from the network of natural fractures, which are damaged by the invasion of mud filtrate during drilling operations. For this study, weighting material and drilling fluid were sampled at the same drillsite. X-ray diffraction (XRD) and X-ray fluorescence analyses confirmed the complex composition of the weighting material: 43.2 ± 3.8 wt% of BaSO4 and 47.8 ± 3.3 wt% of calcite (CaCO3); quartz and illite comprised the rest. The drilling fluid was used to form the filter cake in a high-pressure/high-temperature (HP/HT) filter-press apparatus at a temperature of 300°F and differential pressure of 500 psig. Compared with the weighting material, the filter cake contained less CaCO3, but more nondissolvable minerals, including quartz, illite, and kaolinite. This difference in mineral composition makes the filter cake more difficult to remove. Dissolution of laboratory-grade BaSO4, the field sample of the weighting material, and drilling-fluid filter cake were studied at 300°F and 1,000 to 1,050 psig using an autoclave equipped with a magnetic stirrer drive. Two independent techniques were used to investigate the dissolution process: analysis of the withdrawn-fluid samples using inductively coupled plasma-optical emission spectroscopy, and XRD analysis of the solid material left after the tests. The dissolution efficiency of commercial K5-diethylenetriaminepentaacetic acid (DTPA), two K4-ethylenediaminetetraacetic acid (EDTA), Na4-EDTA solutions, and two “barite dissolvers” of unknown composition was compared. K5-DTPA and K4-EDTA have similar efficiency in dissolving BaSO4 as a laboratory-grade chemical and a component of the calcite-containing weighting material. No pronounced dissolution-selectivity effect (i.e., preferential dissolution of CaCO3) was noted during the 6-hour dissolution tests with both solutions. Reported for the first time is the precipitation of barium carbonate (BaCO3) when a mixture of BaSO4 and CaCO3 is dissolved in DTPA or EDTA solutions. BaCO3 composes up to 30 wt% of the solid phase at the end of the 6-hour reaction, and can be dissolved during the field operations by 5 wt% hydrochloric acid. Being cheaper, K4-EDTA is the preferable stimulation fluid. Dilution of this chelate increases its dissolution efficiency. Compared with commonly recommended solutions of 0.5 to 0.6 M, a more dilute solution is suggested here for field application. The polymer breaker and K4-EDTA solution are incompatible; therefore, the damage should be removed in two stages if the polymer breaker is used.