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Obtaining livestock products from healthy livestock is the main goal of the entire livestock industry. The intensification of animal husbandry is accompanied by the active introduction of modern technologies for keeping, feeding and exploitation. Against the background of technological stress factors in cattle, there is a decrease in the duration of productive use, which is due to high morbidity against the background of a decrease in the immune response. The economic losses associated with postpartum illness are forcing professionals to make more informed decisions about prevention and treatment.It is for this reason that the purpose of our study was to study the spread of postpartum diseases in highly productive cows and the prevention of metabolic disorders in newborn cows with PS-2, Prevention-N-E and PDE with E-selenium.In the course of the analysis of morbidity, it was revealed that after calving cows, obstetric and gynecological pathologies are most often recorded: mastitis (26.5%), endometritis (24.5%), subinvolution of the uterus (24.15%), retention of the placenta (7.15%), ovarian diseases (17.45%). Against the background of inaccuracies in feeding during the transition period, the animals have a deficiency of calcium, glucose, phosphorus, as well as an excess of reference values in terms of aminotransferase metabolism. Against the background of immunocorrection of the body in cows of 1,2 and 3 experimental groups, an increase in the level of calcium, in contrast to the control, is noted by 0.22 mmol / l - PS-2, 0.27 - Prevention-NE and 0.24 mmol / l - PDE+ E-selenium. Similar dynamics was observed in the level of glucose in the blood of cows of the experimental groups, exceeding the control values by 22-38%.The use of PS-2, Prevention-N-E and PDE with E-selenium made it possible to reduce the risk of latent ketosis and hypocalcemia by 2 times, compared with animals that did not receive prophylaxis.The obtained results of biochemical studies prove the stimulating effect of biological products on the mineral metabolism of the body and the absorption of macronutrients.

Relevance. One of the unsolved problems of modern industrial pig breeding remains the problem of preserving the health and realizing the reproductive potential of the breeding stock. In the light of the above, it seems promising to develop, test and introduce into practical veterinary medicine new therapeutic and preventive means that ensure the preservation of health, the actualization of productive and reproductive qualities of animals, the use of which would be economically feasible.Methods. To set up the experiment, 30 heads of suckling sows were selected on the 15th day after the first farrowing. The selected sows were divided into 3 groups based on the breed, reproductive qualities and reproductive health according to the principle of pairs-analogues.Results. It was found that intramuscular injection at a dose of 5 ml per head on the 15th, 20th and 25th days after farrowing of the immunotropic drug PigStim-C to animals of the 1st experimental group, and PigStim-M — to animals of the 2nd experimental group contributes to: reducing the period from weaning to the manifestation of phenomenon of heat and the onset of the optimal period for insemination by 4.5–9.1%; an increase in the fertility of insemination from 90% in the control group to 100%; an improvement in the multiplicity of sows by 8.1–8.6% and a decrease in the number of stillborn piglets by 16.7–33.3%; reducing the number of sows with prolonged farrowing by 2–3 times and, as a result, reducing the occurrence of postpartum pathologies of the reproductive organs, such as metritis-mastitis-agalactia syndrome, as well as to increase the effectiveness of therapeutic measures if pathologies occur; reducing the incidence of young pigs received from these sows during the next farrowing by 36.8–41.5%, an increase in their livability by 1.45–2.97% and an increase in live weight at the end of the growing period by 0.16–0.18 kg, at the end of rearing — by 1.1–1.22 kg, and when removed from fattening — by 3.6–4.0 kg.

Relevance. Against the background of stress and high physiological load, cows experience a lack of energy, the need for which increases many times over in comparison with the dry period, in connection with this, their body is forced to use the reserves of adipose tissue. It is important to timely prevent and monitor the status of cows during the transition period.Methods. The methodology of the work was to study the effectiveness of the use of immunostimulating drugs PS-2, Prevention-N-E and PDE + E-selen. For scientific research, 4 groups of down-calving cows of the Holsteinized Black-and-White breed were selected, 10 animals each. Dry cows of the 1st and 2nd experimental groups received PS-2 and Prevention-N-E intramuscularly at a dose of 10.0 ml three times (40, 20 and 10 days before calving), animals of the 3rd experimental group were injected subcutaneously with tissue preparation PDE (denatured emulsified placenta) at a dose of 20.0 ml and intramuscularly — with a complex mineral and vitamin preparation E-selen at a dose of 10.0 ml 20 days before calving. Biological preparations were not used in animals of the control group.Results. An analysis was made of the prevalence of postpartum metabolic disorders: clinically pronounced hypocalcemia was observed in 5.9% of the newly-calved cows, ketosis — in 11.6%, subclinical hypocalcemia — in 17.7%, and a latent form of ketosis — in 22.7%. Biological preparations PS-2 and Prevention-N-E have a corrective effect on the synthesis of aminotransferases, mineral and carbohydrate metabolism, digestibility of macronutrients, against which background the number of newly-calved cows with subclinical forms of ketosis and hypocalcemia is reduced by 2 times.

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