New substituted 5‐(pyridine‐3‐yl)‐1,3,4‐thiadiazoles, their sugar hydrazones and acyclic C‐nucleoside analogs as well as the corresponding thioglycoside derivatives were synthesized. The synthesized compounds were tested for their antimicrobial activity against Escherichia coli, Bacillus subtilis, Staph aureus, Aspergillus niger, and Candida albicans The obtained results indicated that most of tested compounds exhibited moderate to high antimicrobial activity while few compounds were found to exhibit little or no activity against the tested microorganisms.

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Synthesis and Antimicrobial Activity of New Substituted 5-(Pyridine-3-yl)--1,3,4-thiadiazoles and Their Sugar Derivatives. -New substituted pyridinylthiadiazoles, their sugar hydrazones [cf. (VIII)], acyclic C-nucleoside [cf. (X)] as well as corresponding thioglycoside derivatives [cf. (XX), (XXI)] are synthesized and evaluated for their antimicrobial activity. Most of the tested compounds exhibit moderate to high antimicrobial activity. -(EL-SAYED*, W. A.; METWALLY, M. A.; NADA, D. S.; MOHAMED, A. A.; ABDEL-RAHMAN, A. A.-H.; J. Heterocycl. Chem. 50 (2013) 2, 194-201, http://dx.