No abstract

A new coumarin derivative, coumacasia (1) and eight known compounds, coumarin (2), cinnamaldehyde (3), 2-methoxycinnamaldehyde (4), 2-hydroxycinnamaldehyde (5), coniferaldehyde (6), cinnamic acid (7), 2-hydroxycinnamic acid (8), and cinnamic alcohol (9), were isolated from the methanol extract of Cinnamomum cassia. Their structures were elucidated by spectral data and by comparison with the reported literature. The cytotoxic activities of compounds 1-9 were evaluated with two human cancer cell lines, HL-60 and A-549. Compound 1 showed growth inhibitory effects in the HL-60 and A-549 cell lines with IC 50 values of 8.2 ± 0.5 and 11.3 ± 1.1 μM, respectively. Compounds 3-6, and 8 exhibited moderate cytotoxicity with IC 50 values ranging from 20.5 to 65.6 μM.

Cinnacasolides A (Ia), B (Ib) and C (II) are isolated together with 10 known cinnamaldehyde derivatives.

No abstract

This paper aimed at developing a simple and fast approach using chemometrics processing for direct assay of acyclovir in tablets by NIR (near infrared) spectroscopy in diffuse reflectance mode. In making trials with 5 different tablet matrices, the experimental results showed that regardless the matrix variation, it was always possible to construct a quantitative model with suitable linear range, accuracy and precision for direct assay of acyclovir in tablet from NIR spectra. Therefore, the approach used in this study was suitable for on-site fast assay of APIs in tablets during manufacturing process or in post-marketing surveillance of drug quality.