SUMMARY:We investigated the teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, that received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. Multivariate analysis and Post-Hoc Bonferroni tests were used and relative risk and attributable fraction were calculated. In rats treated with the mixture the number of live fetuses decreased and reabsorptions increased with increasing concentrations of the mixture, as well as the number of abnormal fetuses. Abnormalities consisted mainly in atypical craniofacial morphology, protruding tongue, edema, signs of growth delay and shorter limbs, their frequency and severity increased at higher concentrations of the mixture. We conclude that the ethylene glycol-methyl cellosolve mixture possesses a higher teratogenic potential than each of its constituents separately, producing external fetal abnormalities, growth delay, and increased fetal death.

ARTEAGA-MARTÍNEZ, M.; GARCÍA-PELÁEZ, I.; AGUIRRE-LUNA, O. M. & SAAVEDRA-ONTIVEROS, D. Teratogenic effect of ethylene glycol-methyl cellosolve mixture in rats. I. Reproductive damage. Int. J. Morphol., 28(4):1087-1092, 2010. SUMMARY:We investigated the reproductive damage and teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, which received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. In rats treated with the mixture the number of live fetuses decreased and reabsorptions increased with increasing concentrations of the mixture, as well as the number of abnormal fetuses. We conclude that the ethylene glycol-methyl cellosolve mixture possesses a higher teratogenic potential than each of its constituents separately, producing reproductive damage, external fetal abnormalities, growth delay, and increased fetal death. ARTEAGA-MARTÍNEZ, M.; GARCÍA-PELÁEZ, I.; AGUIRRE-LUNA, O. M. & SAAVEDRA-ONTIVEROS, D. Teratogénesis por etilenglicol-metilcelosolve en ratas. I. Daño reproductivo. Int. J. Morphol., 28(4):1087-1092, 2010.RESUMEN: Se investigó el daño reproductivo y efecto teratogénico de una mezcla de etilenglicol y metilcelosolve en ratas gestantes, las cuales recibieron por vía intraperitoneal una dosis diaria, a diferentes concentraciones de la mezcla, del día 8 al día 20 de gestación. En las ratas tratadas con la mezcla el número de fetos vivos disminuyó y las reabsorciones y el número de fetos anormales aumentaron a mayor concentración de los solventes. Concluimos que la mezcla de etilenglicol-metilcelosolve tiene mayor efecto teratogénico que cuando actúan cada uno de los solventes por separado, produciendo daño reproductivo, anormalidades fetales externas, retraso del crecimiento y aumento de muerte fetal. ARTEAGA-MARTÍNEZ, M.; GARCÍA-PELÁEZ, I.; AGUIRRE-LUNA, O. M. & SAAVEDRA-ONTIVEROS, D. Teratogenic effect of ethylene glycol-methyl cellosolve mixture in rats. I. Reproductive damage. Int. J. Morphol., 28(4):1087-1092, 2010.

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