Irritable bowel syndrome (IBS) is a a chronic functional gastrointestinal disorder, that affects large intestine. The symptoms of IBS include: abdominal pain, discomfort, change in bowel habits and disordered defecation. The causes of irritable bowel syndrome have not yet been fully investigated and determined.Peppermint (Mentha ×piperita) is a hybrid type of mint, a cross between watermint (Mentha aquatica) and spearmint (Mentha spicata). Peppermint oil is produced in the proces of steam distillation of fresh leaves of peppermint.The aim of this study was to evaluate the use of peppermint oil in the treatment of irritable bowel syndrome. Our study material consisted of publications, which were found in PubMed, ResearchGate and Google Scholar databases. The first step was to find proper publications from the last 30 years. The second step was to carry out an overview of the found publications.Based on the results of mentioned studies it can be concluded that peppermint oil is effective in the treatment of irritable bowel syndrome due to providing global symptom improvement and significant reduction of abdominal pain, and its short-term use is safe. However, further research is needed to estabilish the role of peppermint oil in the treatment of irritable bowel syndrome and to determine the optimal duration of treatment, dosage of peppermint oil, and its possible side effects related to long-term usage.

Prediction of the development and susceptibility to acute mountain sickness (AMS) by monitoring oxygen saturation (SpO2)-literature review.

Zinc is one of the most important micronutrients. It is essential for maintaining health. It is supplied with food, therefore an appropriate diet is the basis for maintaining its appropriate level in the body. The cause of the deficiency may be insufficient supply or malabsorption. [2] Deficiency symptoms manifest themselves in the form of ailments from various systems. A relationship has been shown between zinc deficiency and the occurrence of certain diseases, e.g. cardiovascular diseases, diabetes and depression. Supplementation has a beneficial effect in the prevention and alleviation of the course of certain diseases. [1]

High-altitude pulmonary edema (HAPE) is a life-threatening form of non-cardiogenic pulmonary edema, that develops within the first 2-5 days in rapidly ascending individuals at altitudes above 2,500-3,000 m. The clinical features are cyanosis, tachypnoea, tachycardia and elevated body temperature generally not exceeding 38.5°C. It is often severe and potentially fatal manifestation of acute mountain sickness (AMS). The aim of this study was to assess the methods of prevention and treatment of high altitude pulmonary edema (HAPE). Our study material consisted of publications, which were found in PubMed, ResearchGate and Google Scholar databases. The first step was to find proper publications from the last 30 years .The second step was to carry out an overview of the found publications. Gradual ascent and staged ascent are the most effective methods of prevention of HAPE Pharmacologic prophylaxis with nifedipine should only be considered for individuals with a history of HAPE. Before initiating treatment of HAPE differential diagnosis should be done. Descent should be initiated and oxygen therapy should be started when HAPE is suspected or diagnosed. If these methods are unavailable, nifedipine or Gamow bag can be used.

Rheumatoid arthritis is a systemic autoimmune disease of connective tissue of unknown etiology. Specific for it is the involvement of symmetrically small and medium-sized joints, leading to degradation of their structure, stiffening and muscle contractures. It is also characterized by extra-articular and generalized symptoms, such as fatigue, low-grade fever and sweating. It can occur with or without elevated RF and / or ACPA antibodies, causes disability and contributes to premature death. Drugs for this disease can be categorized into disease-modifying drugs as well as glucocorticosteroids and non-steroidal anti-inflammatory drugs. The first-line drug is methotrexate. In case of ineffectiveness of the treatment, biological treatment can be started.