vances in targeted drug delivery applications. Several classes Protein-Polymer Nanoparticles for Delivery of nanomaterials, including gold shells, carbon nanotubes, of Therapeutics dendrimers, lipids, and polymers, are being investigated as matrices for developing multifunctional nanoparticles that not Ashutosh Chilkoti only carry the drug payload but also contain the targeting and imaging moieties. A myriad of specific cell-targeting ap-Center for Biologically Inspired Materials and Materials proaches are being used, which includes not only antibodies Systems and Department of Biomedical Engineering, but also small molecular ligands, peptides, and other biologics. Duke University, Durham, NC, USAWe have been investigating delivery of genes and small inter-I will, in my first example, describe a class of proteinfering RNAs (siRNAs) using the polycationic biodegradable polymers-artificial recombinant polypeptides-that spontapolymer, chitosan, and its derivatives. Examples of successful neously undergo self-assembly upon conjugation to the cancer applications of combined genomics and nanotechnology for chemotherapeutic doxorubicin (Dox) and other small hydrocancers, with a particular focus on delivery of polynucleotides phobic molecules. These chimeric polypeptides (CPs) consist to prostate, lung, and ovarian tumors, will be discussed. of a hydrophilic, biodegradable polypeptide segment that is attached to a short Cys-rich segment. Covalent modification of the Cys residues with a structurally diverse set of hydrophobic Cell-Mediated Drug Delivery to the Lungs small molecules, including Dox, leads to the spontaneous forby SNAP Methodology mation of nanoparticles for a range of CP compositions and molecular weights. The CP-Dox nanoparticles are ϳ40 nm in Don F. Cameron diameter, release drug at pH 5.0 (relevant to endolysosomal release), are taken up by cells, show subsequent localization Department of Pathology & Cell Biology, University of the drug to the nucleus, and are cytotoxic. Notably the CPof South Florida College of Medicine, Tampa, FL, USA Dox nanoparticles have a fourfold higher maximum tolerated dose than free drug and induce near complete tumor regression Chitosan nanoparticles are effectively used to deliver drugs in a murine model following a single dose. In the second exto the lungs by inhalation methodology for asthma and COPD. ample, I will discuss a new protein-polymer conjugate with However, delivery of drug-containing nanoparticles to the interesting pharmacological properties. I will describe two new deep lung in this way is poor (ϳ10-30%) and difficult to conand general routes to grow a PEG-like polymer, poly[oligo trol, especially when there are obstructive airway issues. To (ethylene glycol) methyl ether methacrylate] [poly(OEGMA)], overcome these limitations, isolated and prelabeled rat Sertoli with low polydispersity and high yield solely from the Ncells (SCs) were preloaded with labeled chitosan nanoparticles terminus or C-terminus of a protein by in situ atom-transfer that contained the ...
This event was the fourth of the NANOS-MAT conference series. NANOSMAT conferences fundamentally facilitate knowledge exchange and provide an interactive platform for researchers and engineers from industry, research laboratories and academia to network and to exchange knowledge in the fields of Nanoscience and Nanotechnology.NANOSMAT-2009 aimed at bringing together state-ofthe-art developments on all aspects related to the processing, characterization and applications of surfaces, coatings and novel nanostructured materials. The conference also hosted an exhibition and three short courses on aspects of Nanoscience and Nanotechnology.We had received just over 450 abstracts and the oral presentations were conducted in three parallel sessions. The conference consisted of the following four symposia: (1) Carbon nanostructured materials, (2) Surface science and engineering: from bulk to nano scale, (3) Nanotechnology Approaches, Nanomaterials and Thin Films for Energy Technologies and (4) Nanomedicine and Nanobiotechnology.This special section of Journal of Nanoscience and Nanotechnology has been guest edited by five editors, ABOUT THE GUEST EDITORSDr. Nasar Ali currently holds the post of a chief scientific officer at CNC Coatings company based in Rochdale, UK. Prior to this Dr. Ali was a faculty member (Asst. Professor) at the University of Aveiro in Portugal where he founded and led the Surface Engineering and Nanotechnology group. Dr. Ali has extensive research experience in hard carbon-coating materials, including nanosized diamond coatings and CNTs, deposited using CVD methods. He has over 115 international referred research publications, including five book chapters. Dr. Ali serves on a number of committees for international conferences based on nanomaterials, thin films and emerging technologies (nanotechnology) and chairs two very successful, NanoSMat and MPA, conferences. He served as the fellow of the Institute of Nanotechnology, for 2 years on invitation, and is also the founder and the President of the Society of Nanoscience and Nanotechnology. Dr. Ali has edited several books on surface coatings, thin films and nanotechnology for leading publishers and was also the founder of the Journal of Nano Research. Dr. Ali was the recipient of the Bunshah prize for presenting his work on time modulated CVD during ICMCTF-2002 conference in
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