AbstrakTalasemia merupakan penyakit kronik yang membutuhkan transfusi setiap bulan, karena eritrosit lebih cepat lisis dibandingkan eritrosit normal. Komplikasi dan efek penyakit ini banyak, antara lain pertumbuhan, perkembangan, dan status gizinya. Penelitian ini bertujuan mengetahui gambaran status gizi anak talasemia β mayor Penelitian ini adalah penelitian deskriptif yang dilakukan pada bulan Februari 2012 -Maret 2013 di RSUP Dr. M. Djamil Padang dengan sampel anak talasemia β mayor. Pemeriksaan yang dilakukan adalah mengukur tinggi badan, berat badan, dan lingkar lengan. Hasil pemeriksaan dimasukkan dalam tabel persentil NCHS dan penilaian status gizi berdasarkan Departemen Kesehatan Repubik Indonesia.Hasil penelitian ini terdapat 15 anak talasemia β mayor, dengan rata-rata umur kelompok 5-10 tahun. Frekuensi terbanyak indeks tinggi badan per umur yaitu 70%-90% (60%.). Frekuensi terbanyak indeks berat badan per umur adalah 60%-80% (66.7%). Frekuensi terbanyak indeks lingkar lengang atas per umur adalah 70%-85% (80%). Simpulan dari hasil penelitian status gizi anak talasemia β mayor adalah gizi kurang. AbstractThalassemia is a chronic disease who needs blood tranfusion every month because the abnormal erythrocyte has short life time compared with the normal erythrocyte. There are so many complications and effects of this disease, such as growth and nutritional status. The aim of this research is to describe chlidren's nutritional status with thalassemia beta major. This research is a descriptive research. It has been done since February 2012 -March 2013 at RSUP Dr. M. Djamil Padang. The sampling is children with thalassemia beta major. The examination are stature, weight, and upper arm circumference and the result is entered into NHCS percentil and assessment of Nutritional based on health department of Indonesia. From this research, there are 15 children who are suffering thalassemia beta major, and most of them is about 5-10 years old. The highest insident of stature per age index is 70-90% (60%). The highest insident of weight per age index is 60%-80% (66,7%). The highest insident of upper arm circumference per age is 70%-85% (80%).The conclusion of this research that the nutritional status children with thalassemia beta major is low nutrional.

Objective: To report a case of Turner syndrome diagnosed in prenatal care.Method: A case report.Case: Case of Mrs. Y 26-year-old woman G2P1A0L1 diagnosed on 19-20 weeks of gestation with Turner syndrome. Ultrasound examination findings were hydrops fetalis on the neck region, multiple septated cystic masses, subcutaneous edema, ascites, and hydrothorax. Subsequently, amniocentesis was performed and the chromosome analysis result showed Turner syndrome (45, X0). The patient was induced vaginal delivery on 22-23 weeks of pregnancy due to intrauterine fetal death indication. The baby was born with ambiguous genitalia, birth weight 500 grams, birth length 22 centimeters, and Apgar’s score was 0/0. The congenital anomalies discovered include subcutaneous edema, ascites, hydromacolly, and hydrops fetalis.Conclusion: Turner syndrome can be diagnosed at a prenatal period by ultrasound examination. Keywords: Turner Syndrome, Hydrops Fetalis, Ultrasonography

Iron deficiency anemia that followed by low serum ferritin levels in early pregnancy has an indirect impact on decreasing the expression of Brain Derived Neurotrophic Factor (BDNF) in the maternal hippocampus. BDNF together with its receptor tyrosine kinase B (TrkB) induced the expression of metalloproteinase-9 (MMP-9) which plays an important role in blastocyst implantation, trophoblast invasion and placental development. Decreasing BDNF levels can interfere with those process which caused imbalance of pro-angiogenic and anti-angiogenic factors such as VEGF, PIGF, sFlt1 and sEng that leads to preeclampsia. This study aims to determine the correlation between ferritin and BDNF serum levels in preeclampsia.Keywords: Preeclampsia, ferritin, iron deficiency anemia, Brain Derived Neurotrophic Factor