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Previous studies demonstrated that antigen B (AgB), a major antigen of timothy grass pollen, modified by photooxidation (Ox-AgB), does not react with rabbit, human, or mouse antibodies directed against AgB and does not induce antibodies reactive with either native or modified AgB. In this paper we show that Ox-AgB retains an estimated 70% of the lymphocyte-activating properties and a significant amount of the T-cell-priming capabilities of AgB.

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Rhesus monkeys injected intravenously with TNP-KLH produced homocytotropic antibody separable into two components on ion exchange chromatography, a heat-labile γ₁- and a heat-stable γ₂-immunoglobulin. Homocytotropic antibody was directed against the TNP group only, though both groups of determinants gave rise to large amounts of precipitating antibody. Arthus reactions induced by TNP on heterologous carrier were more severe than those caused by KLH. Prolonged TNP-induced reactions resembled delayed hypersensitivity reactions grossly and histologically. Anaphylaxis occurred in a few of the animals in response to TNP-KLH, but not to KLH alone, although no relationship to levels of homocytotropic antibody was discernible.