A study of the growth of needle crystals of monosodium urate was undertaken with the aim of finding inhibitors which might be able to prevent the acute gout attack. Rates of crystal growth at various levels of supersaturation are described. Two potent crystal growth inhibitors, Bismarck brown and methylene blue, were found. They are shown to be adsorbed onto monosodium urate. THAM was found to accelerate needle crystal growth.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.