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Purpose1. To improve the causality analysis performance, a novel causality detector based on time-delayed convergent cross mapping (TD-CCM) is proposed in this work. 2. Identify the root cause of plant-wide oscillations in process control system.Design/methodology/approachA novel causality analysis framework is proposed based on denoising and periodicity-removing TD-CCM (time-delayed convergent cross mapping). We first point out that noise and periodicity have adverse effects on causality detection. Then, the empirical mode decomposition (EMD) and detrended fluctuation analysis (FDA) are combined to achieve denoising. The periodicities are effectively removed through singular spectrum analysis (SSA). Following, the TD-CCM can accurately capture the causalities and locate the root cause by analyzing the filtered signals.Findings1. A novel causality detector based on denoising and periodicity-removing time-delayed convergent cross mapping (TD-CCM) is proposed. 2. Simulation studies show that the proposed method is able to improve the causality analysis performance. 3. Industrial case study shows the proposed method can be used to analyze the root cause of plant-wide oscillations in process control system.Originality/value1. A novel causality detector based on denoising and periodicity-removing time-delayed convergent cross mapping (TD-CCM) is proposed. 2. The influences of noise and periodicity on causality analysis are investigated. 3. Simulations and industrial case shows that the proposed method can improve the causality analysis performance and can be used to identify the root cause of plant-wide oscillations in process control system.