Background: Head and neck squamous cell carcinoma (HNSCC) is one of the most serious diseases affecting populations worldwide and lymph node metastasis is a key pathological feature of HNSCC which predicts poor survival. However, the molecular mechanisms associated with the development of lymph node metastasis in HNSCC have not been fully elucidated.Methods: Differentially expressed genes (DEGs) were identified in two HNSCC datasets (GES6631 and GES58911). Functional annotation analysis was constructed via Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. Meanwhile, the proteinprotein interaction (PPI) network and module analysis using Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape were carried out to identify the hub genes. The expression differences, overall survival (OS), and disease-free survival (DFS) of hub genes were analyzed by Gene Expression Profiling Interactive Analysis 2 (GEPIA2) and verified by immunohistochemistry (IHC) from Human Protein Atlas (HPA). Moreover, receiver operating characteristic (ROC) curve analysis was conducted to judge whether those hub genes had good diagnostic and prognostic ability, and the web tool Tumor Immune Estimation Resource (TIMER) was used to analyze the correlation of hub genes' expression and immune infiltration.Results: In total, 913 DEGs including 476 upregulated and 437 downregulated genes were identified.The genes Aurora kinase A (AURKA), CyclinB1 (CCNB1), Cyclin-dependent kinase regulatory subunit 1B (CKS1B), Serpin Family H Member 1(SERPINH1), and Transforming growth factor-beta-induced protein (TGFBI) were screened out as hub genes and were associated with lymph node metastasis, showing notably abnormal expression in HNSCC samples, and the high expression of all the hub genes in HNSCC patients was related to worse overall survival. Conclusions:The genes AURKA, CCNB1, CKS1B, SERPINH1, and TGFBI may be involved in the lymph node metastasis of HNSCC and reveal the potential to serve as molecular biomarkers in the diagnosis of HNSCC. This study may help to elucidate the molecular mechanisms of the development of lymph node metastasis and facilitate the selection of targets for the treatment and diagnosis of HNSCC.

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Abstract. During the emergence of IaaS (infrastructure as a service), the traditional model of enterprise information is broken, and the IT resources of the enterprise are fully used, and the requirements of enterprise, low cost to build the network information platform, is satisfied. In contrast to the existing mainstream open source cloud computing project, OpenStack has been chosen to provide the flexible environment foundation for the enterprise private cloud. It is finally presented that the enterprise private cloud platform architecture based on OpenStack.

Abstract. In order to realize the sharing and full use of the distributed and stochastic manufacturing resources, a covering network structure of two-layer like Chord ring is constructed. According to the Chord protocol, a distributed manufacturing resource sharing system model is proposed, making logic subrings by the type of resources and the logic main rings by the super nodes. The relay of the resource rings and the convergence of different types of resources for application are completed by super nodes. On this basis a framework model of manufacturing resource sharing system is built. The sharing system prototype instance is given finally.