Background. To determinate the association relationship of breast cancer bone metastasis and cancer characteristics and molecular subtype. Furthermore, to evaluate the impact of molecular subtype on prevalence and prognosis of bone metastasis from the breast cancer base on a large population real-word program, the Surveillance, Epidemiology, and End Results (SEER) database. Methods. We collected and analyzed the data obtained from SEER, which showed molecular subtype information for each patient. The prevalence and outcome of bone metastasis in breast cancer were estimated as per the different molecular subtypes. Results. Occurrence of bone metastasis in conformity with four different molecular subtypes in all 42684 breast cancer patients was 6.2, 9.4, 7.9, and 6.4%, respectively. The most unfavorable subtype was the triple-negative breast cancer (TNBC), followed by the luminal A, luminal B, and HER2 subtypes (hazard ratio [HR] of luminal A compared with TNBC, 0.533, 95% confidence interval, 0.444–0.641; HR of luminal B, 0.482, 95% CI 0.419–0.555; HR of HER2 subtype, 0.542, 95% CI 0.484–0.608). Brain metastasis impacts overall survival (OS) ( p < 0.001 ) fundamentally, and visceral metastases also significantly decreased OS ( p < 0.001 ). Conclusion. Bone metastasis patients present a more favorable oncological survival consequence than other metastases, and the TNBC subtype with bone metastasis showed the poorest tumor outcome compared with the other three molecular subtypes.

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In order to effectively suppress the resonance problem of photovoltaic grid-connected system, an optimization method of active damping resonance suppression is proposed by combining active damping notch control method and active damper method. The resonance mechanism of photovoltaic grid-connected system is analyzed based on frequency domain analysis method. The notch filter is added into the active damping control method, and the active damping of the system is enhanced by using the notch characteristics. The virtual impedance is introduced in parallel with the active damper at the common bus to increase the system damping, which can suppress the system resonance effectively. Finally, the Matlab/Simulink simulation results show that the resonance suppression of photovoltaic grid-connected system can obviously improve the voltage waveform of the common bus, and make the total harmonic distortion rate of the common bus reach 1.07%, which is 0.55% lower than that of the single active damping notch control method, and the higher harmonic suppression effect is more obvious.