Altered DNA methylation at various CpG sites was associated with exposure to mercury, lead or BPA, providing candidates to be investigated using a larger study sample, as the results may reflect an independently associated predictor (e.g. socioeconomic status, diet, genetic variants, altered blood cell composition). Further studies accommodating variations in these factors will be needed to confirm these associations and identify their underlying causes.

Objective Investigate associations between serum BPA concentrations and follicular response to exogenous ovary stimulation. Design Fasting serum was prospectively collected on the day of oocyte retrieval and assessed for unconjugated BPA using high-performance liquid chromatography (HPLC) with Coularray detection. Multivariable linear regression and negative binomial regression were used to assess associations between concentrations of BPA and outcome measures. Models were adjusted for race/ethnicity, antral follicle count at baseline, and cigarette smoking. Setting A reproductive health center. Patients Forty-four women undergoing in vitro fertilization (IVF). Main outcome measures Peak-estradiol level (E2) and the number of oocytes retrieved during IVF. Results The median unconjugated serum BPA concentration is 2.53 ng/ml (range 0.3–67.36 ng/ml). Bisphenol A is inversely associated with E2 (β=−0.16; 95% confidence interval (CI) −0.32, 0.01), as well as with E2 normalized to the number of mature-sized follicles at the hCG trigger (β=−0.14; 95%CI −0.24, −0.03). No association is observed for BPA and the number of oocytes retrieved (adjusted risk ratio=0.95; 95%CI 0.82, 1.10). Conclusions Bisphenol A is associated with a reduced estradiol response during IVF. Although limited by the preliminary nature of this study, these results merit confirmation in a future comprehensive investigation.

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Here we assess bisphenol A (BPA) in couples undergoing in vitro fertilization (IVF) and indicators of embryo quality; embryo cell number (ECN) and embryo fragmentation score (EFS). Twenty-seven couples provided serum on the day of oocyte retrieval. Unconjugated BPA was measured by HPLC with Coularray detection. Odds ratios (OR) were generated using ordinal logistic regression including female and male BPA concentrations, age and race, and day of embryo transfer for ECN. Inverse associations are suggested for male BPA with ECN (OR=0.70, P=0.069), and EFS (OR=0.54, P=0.009), but not for women. Male BPA exposure may affect embryo quality during IVF.

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