Background: A disturbed glucose metabolism is quite common during pregnancy. It is due to the diabetogenic potential of pregnancy and responsible for many obstetric complications. The glycated hemoglobin is one of the markers used to depict these disorders. Higher concentrations of this marker would be associated with unfavorable results of pregnancy. Objective: To describe the profile of HbA1c in non-diabetic preeclamptic pregnant women and to establish the association between the values of this marker and the maternal and fetal complications. Materials and Method: This is a case-control study of 142 pregnant women in their second and third trimester. They were followed in the maternity hospitals of University Clinics and the General Reference Hospital in Kinshasa, Democratic Republic of Congo between May and October 2019. The sampling of preeclamptic pregnant women was exhaustive.

Context: Preeclampsia is a multisystem endothelial disease characterized by hypertension of pregnancy and glomeruloendotheliosis resulting in significant proteinuria. These days, the weight determination of urinary proteins by 24-hour proteinuria (P24) remains the reference method for biologically confirming this condition. However, the completion of the exam appears to be very burdensome with a long waiting period for results. Hence the need to use a simple alternative method such as the proteinuria / creatininuria ratio (PCR). Aims: Improve the diagnosis and management of preeclampsia by using a simple, less restrictive but reliable diagnostic method. Methodology: The study compared the results obtained from P24 versus PCR in confirming the diagnosis of preeclampsia in 149 Congolese women in whom the disease was suspected thanks to the urine dipstick. The cut-off values used for the diagnosis of preeclampsia were, for P24, a proteinuria> 300 mg / 24 h and for PCR a value> 30 mg / mmol. Results: Of the 149 pregnant women in whom the diagnosis of preeclampsia was suspected using the urine dipstick, only 85.9% had a P24> 300 mg. This diagnostic confirmation rate was similar to that obtained with PCR (86.6%). A linear correlation was found between P24 and PCR in the quantification of proteinuria and in the diagnosis of preeclampsia (r² = 0.627, p <0.004). Comparing the pathological values diagnosed by the two methods, the agreement was 89.1% (kappa = 0.767). The PCR showed an excellent predictive performance of maternal-fetal complications at the optimal threshold of 30.8 mg / mmol corresponding to a sensitivity of 96.6% and a specificity of 95% (Youden index 0.866). This threshold was 323 mg / 24h corresponding to a sensitivity of 84% and a specificity of 61.9% (Youden index 0.459) for P24. Conclusion: PCR seems to be a good alternative to P24 in confirming the diagnosis of preeclampsia in the settings most affected by this pathology

Goal: The present study aimed to determine the profile of seric calcium and magnesium in pre-eclamptic and eclamptic pregnant women of Kinshasa province in the Democratic Republic of Congo where preeclampsia is characterized not only by a high incidence, but also by a seasonal variation probably related to nutritional intake. Study Design: This is a case-control study that took place during the period from September 2014 to March 2015 in four quaternary and tertiary maternity hospitals in Kinshasa. A total of 113 healthy pregnant women (controls) and 112 pre-eclamptic and eclamptic pregnant women (cases) were included in this study. Seric calcium and magnesium were measured in all these gravidas by the principle of spectrophotometry with a HUMALYSER Primus semi-automaton. Results: The mean age of those gravidas was 26.8 ± 6.3 years (26.7 vs 26.9, p = 0.11). The majority of these gravidas were primiparous. The mean gestational age in both groups was 31.35 ± 0.9 weeks (32.1 vs 30.6, p = 0.21). The average seric calcium value was 4.47 ± 0.23 mEq /L in healthy pregnant women compared to 3.80 ± 0.71 mEq/l in pre-eclamptics (P < 0.001). The mean of seric magnesium was 1.56 ± 0.15 mg/dL in healthy pregnant women compared to 1.20 ± 0.41 mg/dL in pre eclamptics (P < 0.001). Seric calcium and magnesium values were low in the pre-eclamptic group and lower in the eclamptic group (P < 0.001). Conclusion: This study establishes a relationship between the low concentration of seric calcium and magnesium with pre-eclampsia and eclampsia, which could

Context: Polycystic ovary syndrome (PCOS) is considered a syndrome related to the metabolic syndrome with a high risk for developing diabetes mellitus. The evaluation of the glycated hemoglobin (HbA1c) seems to be an interesting tool to detect states of hyperglycemia that may be associated with this syndrome and to understand her pathophysiology. Aims: The purposes of this study are to determine the profile of HbA1c in Congolese women with PCOS, to determine the frequency of states of hyperglycemia and to assess the impact of this marker on clinical signs on this syndrome. Material and methods: This is a case-control study of 130 Congolese subfertile women; 65 with a diagnosis of PCOS and 65 others without PCOS. This is conducted from June 2016 to June 2019 among Congolese women of childbearing age.How to cite this paper:All these women were recruited at the subfertility outpatient clinic of the University Hospital of UNIKIN as well of the YANGA medical centers in Kinshasa, Democratic Republic of Congo. Sickle cell disease was excluded as also the cases of anemia. HbA1c was assayed via the immunoturbidimetric method and the results interpreted according to the ADA recommendations with a pathological cut-off point ≥ 6.5%. Results: Mean hemoglobin was 11.6 ± 1.2 g/dl (11.5 ± 1.1 g/dl vs. 11.8 ± 1.4 g/dl, P = 0.568). The proportion of diabetics was 1.6% (1.6% vs. 1.5%, P = 0.74). Higher HbA1c values were noted in the PCOS group compared to the control group (7.3% ± 2.1% vs. 5.6% ± 0.6%, P < 0.001). The multivariate analysis showed a strong correlation between elevated HbA1c levels and PCOS , P < 0.001). In the PCOS group, higher HbA1c values were significantly correlated with a higher socio-economic status ), P = 0.018) and with obesity (OR 3.48 IC (1.31 -7.13) P = 0.029). A perfect, positive and significant linear correlation was found between HbA1c and fasting blood glucose (r = 0.807). 60% of women in the PCOS group had pathological values of HbA1c (≥6.5%) compared to 7.7% in the control group (P < 0.001). Oligomenorrhea was found more significantly in patients with pathological HbA1c values (≥6.5%) compared to those with values < 6.5% (P = 0.003). Conclusion: This study found that in our population 60% of women with PCOS had states of hyperglycemia, demanding systematic screening of glucose metabolism disorders in women with this syndrome.