The paper arises from a reflection about the concept of well-being from different knowledge domains in order to articulate its emergence in chronical diseases. In principle, this article gathers epistemologic and disciplinary perspectives in relation to well-being and comprehensions about the process of health-disease. In pursuance of advancing in the proposed articulation of understanding and contributing to the emergence of well-being in the relationship of people in chronic disease, their families and health professionals. The task consists in going beyond predictions and determinisms that define the disease and its intervention from the perspective of the biomedical model, and convening professional interlocutions from diverse disciplinary fields with people experiencing illness and their families; where the experience of disease and well-being are emergent of the joint construction between them, and benefits them in an exercise of collaboration and co-responsability. It is expected to enrich the comprehension and approach of health-disease situations with the actors directly involved in these processes; at the same time, it seeks to contribute in the generation of political frameworks and to society in its relation with the healthcare system, intending to fulfill the purpose of constructing welfare for all human beings.