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nd conoenital anomalies 43% greater (P<.02) in offspring of 2 -s than of nonsmokers. 46,865 placentas were available i n which maternal smoking i s t o r i e s had ,been recorded. Abnormalities i n these placentas rovide plausible explanations f o r most of the excess f e t a l and eonatal mortality associated with cigarette smoking. The placentas o f the cigarette smokers had a number of structural abiormali t i e s characteristic of reduced maternal perfusion, includ ing o b l i t e r a t i v e e n d a r t e r i t i s and cytotrophoblastic hyperplasia in v i l l i and necrosis of the decidua basalis a t the margin of :he placenta. Structural abnormalities were absent in the a r t e r i e s of the decidua. Nicotine temporarily reduces uterine blood flow and thus provides a plausible explanation f o r the underperfusion. Increased carboxyhemoglobin in maternal blood may also 2lav a role i n the f e t a l and neonatal deaths. GAS LIQUID CHROWTOGRAPHY OF KERATAN SULFATE IN THE920 1 KNIEST SYNDROME. Richard Nyako, Reuben Matalon.

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5 newborn infants, whose mothers acknowledged steady use of marihuana prior to and during pregnancies, displayed symptoms of intrauterine growth retardation, neurological problems, and abnormal morphogenesis. These findings fit in with the experimental studies and surveys of pregnant human populations which have indicated that cannabis products have teratogenic potential, though rigorous proof must await further information.