Background:The hallmark of Parkinson disease is ␣-synuclein aggregation, whose cytotoxic effects are reproducible in yeast. Results: ␣-Synuclein aggregate clearance is impaired by vacuolar protease inhibitor PMSF but not by proteasome inhibitor MG132. Conclusion: Yeast recovers from ␣-synuclein-induced toxicity by clearing aggregates via autophagy and vacuolar pathways. Significance: The data provide insight into the mechanisms used by yeast cells to clear toxic aggregated proteins.

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