Stoichiometric reduction of artemisinin to dihydroartemisinin (DHA) has been successfully transferred from batch to continuous flow conditions with a significant increase in productivity and an increase in selectivity. The DHA space-time-yield of up to 1.6 kg h −1 L −1 was attained which represents a 42 times increase in throughput compared to that of conventional batch process.
The
direct chemical conversion of cocoa butter triglycerides, a
material available as a postmanufacture waste stream from the food
industry, to 1-decene by way of ethenolysis is reported. The conversion
of the raw waste material was made possible by use of 1 mol % of the
[RuCl2(iBu-phoban)2(3-phenylindenyl)]
catalyst. The process has been investigated in both batch and flow
conditions, where the latter approach employs a Teflon AF-2400 tube-in-tube
gas–liquid membrane contactor to deliver ethylene to the reaction
system. These preliminary studies culminate in a continuous processing
system, which maintained a constant output over a 150 min period tested.
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