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Summary Glutathione peroxidase deficiency is the most recently described erythrocyte enzyme abnormality. This enzyme occupies a critical position in the pathways leading to the decomposition of peroxides in the erythrocyte. On the basis of our studies of patients with GSH‐P deficiency, it appears that a spectrum of disease quite similar to that found in G‐6‐PD deficiency is present; this includes compensated haemolytic disease, drug‐induced haemolysis and neonatal jaundice.

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