Self-regulation of diabetes depends in part on common-sense models of symptoms and blood glucose fluctuations. Symptom perception and subjective estimation of blood glucose were studied in 52 adult, difficult-to-control, non-insulin-dependent diabetics using a structured interview and laboratory blood-glucose measurement. Most patients believed they could detect hyperglycemia. Symptoms linked by patients to hyperglycemic and hypoglycemic episodes did overlap with symptoms traditionally associated with those states. Some patients may experience dysphoria during glycemic swings to which multiple symptom labels are applicable, although prominent exceptions and idiosyncratic symptoms were evident. Estimation of current blood glucose using an ordinal scale suggested some capacity for discriminating blood glucose levels. Numerical estimates of Chemstrip values were correlated with actual values, but far too inaccurately for purposes of self-regulation. Research is needed to clarify whether subjective symptom perception and blood glucose estimation helps or hinders self-regulation of diabetes.

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Neurosteroid Analogues. Part 5. Enantiomers of Neuroactive Steroids and Benz[e]indenes: Total Synthesis, Electrophysiological Effects on GABA A Receptor Function and Anesthetic Actions in Tadpoles. -As an extension of a recent study the compounds (I) and (II) are prepared and the title biological effects are investigated. The results support the hypothesis that the modulation of the GABA A receptor plays a predominant role in steroid-induced anesthesia. -(HU, Y.; WITTMER, L. L.; KALKBRENNER, M.; EVERS, A. S.; ZORUMSKI, C. F.; COVEY, D. F.;

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