No abstract

Pressinoic acid, the cyclic disulfide of cysteinyltyrosylphenylalanylglutaminylasparaginylcysteine which contains the pressin ring structure of the posterior pituitary hormones arginine-and lysine-vasopressin, has been synthesized by the stepwise p-nitrophenyl ester method. The closely related compounds deaminopressinoic acid, pressinamide, and deaminopressinamide have been synthesized by similar methods, and all have been tested for some of the biological activities shown by the parent hormones. None of the compounds showed any pressor or avian vasodepressor activities. All except pressinoic acid exhibited a slight degree of oxytocic activity, in the range of 0.05-0.5 unit/mg. No inhibitory properties were noted in the systems studied.

No abstract

No abstract