The objective of this study was to verify the possible association between Glutathione Stransferase genetic polymorphism and functional physical aspects in the elderly with and without type 2 diabetes mellitus (DM2), as well as the increased susceptibility to its development. To carry out this cross-sectional study, 5 mL of blood was collected from 45 elderly people. The polymorphism was detected by the multiplex polymerase chain reaction (GSTM1 and GSTT1 polymorphisms). Functional physical aspects were assessed using physical tests. For statistical analysis, the Shapiro-and Qui Square tests ‫)²א(‬ were used. The presence of the GSTM1 and GSTT1 genes were more prevalent. There was a significant association between GSTT1 null genotypes and the presence / absence of DM2. No association was found between genotypes and functional physical aspects. It is concluded that the nullity of the GSTT1 genotype is associated with the susceptibility of DM2, but without a statistically significant relationship with functional physical aspects.

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