Background A liquid chromatography (LC) stability-indicating method was developed and validated for the quantitative determination of bilastine in coated tablets. Objective The procedure was validated for specificity, linearity, robustness, precision, and accuracy. Plackett-Burmann experimental design was used to determine the robustness of the method. Method Chromatographic separation was performed on a Shim-pack® RP-18 column with fluorescence detection. The degradation products formed under oxidative conditions were isolated and identified using high-resolution mass spectrometry (HRMS). In silico prediction of degradation products and in silico toxicity studies were also performed. Results The LC method presented good recovery and precision (intraday and interday), the response was linear in a range of 0.20 to 0.70 μg mL−1, and the results demonstrated the robustness of the analytical method under the evaluated conditions. Conclusions The degradation products were identified as benzimidazole (DP1) and amine N-oxide of bilastine (DP2). The results for the toxicity studies demonstrated the high mutagenic potential of DP1 and hepatotoxicity and hERG I inhibitor effects of DP2. Highlights Bilastine degradation products were identified as benzimidazole and amine N-oxide using HRMS.

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A principal novidade das eleições presidenciais de 2018 no Brasil foi o movimento Mulheres unidas contra Bolsonaro, tendo aglutinado em torno da consigna #EleNão diversos setores organizados da luta feminista e milhões de mulheres sem filiação alguma, inclusive sem experiência de prática política. O Movimento que nasceu nas redes sociais acumulou força e agregou mulheres de forma tão expressiva que viabilizou sua presença nas ruas e demonstrou-se capaz de realizar a difícil tarefa de agregar setores políticos que têm sido incapazes de cooperar entre si e de construir uma frente de luta ampla, unificada e, ao mesmo tempo, plural. Através de análise qualitativa, pretendemos identificar a natureza do movimento Mulheres unidas contra Bolsonaro e compreender por que foram as mulheres o principal grupo social a mobilizar-se contra o candidato do PSL.

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