One main psychiatric disorder found in humans is ASD (Autistic Spectrum Disorder). The disease manifests in a mental disorder that restricts humans from communications, language, speech in terms of their individual abilities. Even though its cure is complex and literally impossible, its early detection is required for mitigating its intensity. ASD does not have a pre-defined age for affecting humans. A system for effectively predicting ASD based on MLTs (Machine Learning Techniques) is proposed in this work. Hybrid APMs (Autism Prediction Models) combining multiple techniques like RF (Random Forest), CART (Classification and Regression Trees), RF-ID3 (RF-Iterative Dichotomiser 3) perform well, but face issues in memory usage, execution times and inadequate feature selections. Taking these issues into account, this work overcomes these hurdles in this proposed work with a hybrid technique that combines MCSO (Modified Chicken Swarm Optimization) and PDCNN (Polynomial Distribution based Convolution Neural Network) algorithms for its objective. The proposed scheme’s experimental results prove its higher levels of accuracy, precision, sensitivity, specificity, FPRs (False Positive Rates) and lowered time complexity when compared to other methods.