Background: The prevalence of chronic kidney disease (CKD) is increasing worldwide. The progression of CKD aetiology increases the probability of death, which lowers quality of life (QOL). Therefore, we studied complications encountered in CKD patient undergoing hemodialysis at tertiary health center. Methods: This is a cross sectional, observational study conducted among 100 patients for 24 months duration. All CKD patients who were undergoing maintenance hemodialysis at tertiary health care center in Vidharba, India. Patients with CKD (stages 3-5) who required hemodialysis, regardless of gender, were included, as were all patients older than 12 years old. Results: We studied 100 CKD patients undergoing hemodialysis in which 33 (33%) were females and 67 (67%) were males. Hypotension was the most common intradialytic complication (34.2%), followed by muscle cramps (19.5%) and rigors (17.5%). Other complications such as hypoglycemia, nausea, vomiting, chest pain, itching, arrhythmias, and pulmonary edema were reported at lower frequencies. The study found no significant association between age, gender and intradialytic complications. (P value= 0.072). Conclusion:Based on the outcomes of the study, we can conclude that hypotension is the most frequent intradialytic complications followed by, hypoglycemia, nausea/vomiting, muscle cramp, rigors, chest pain, itching, arrhythmias and pulmonary edema. Majority of patients were found to be comorbid having hypertension, diabetes which again are the factors responsible for worsening of disease.