Objective: To study serum lipid profile between 13-20 week of pregnancy & to look for correlation, if any, of serum lipid levels in pregnancy with preeclampsia and to find out correlation, if any, between serum lipids profile and fetomaternal outcome. Material and methods: We carried out a Longitudinal, Descriptive type of observational study in the department of Obstetrics and Gynecology at SDMH, Jaipur from June 2016 to April 2017.Total 125 patients were enrolled in study fulfilling inclusion and exclusion criteria between 13-20 weeks of gestation at SDMH, Jaipur, 14 patients were lost during follow up finally 111 patients remained for analysis .Serum lipid profile was done in all patients and these were followed till delivery for presence and absence of preeclampsia. Results: The mean level of TC in participants developed preeclampsia was 224.36±43.68mg/dl. This was significantly higher as compared to normotensive group 180.77±36.58mg/dl. Conclusion: Early prediction of preeclampsia can be used as a tool for primary prevention before the development of the disease. There is no single specific test available to predict the preeclampsia till date. So there is need of further research to discover the specific test to predict preeclampsia