No abstract

Our results demonstrated that the thicker membrane showed the least soft tissue ingrowths and promoted better bone formation at 6 months compared with a thinner one.

Order picking (OP) is a process that occurs in warehouses of unitized goods and it includes all activities that follow the retrieval of demanded goods, according to demanded type and quantity, with the intention of meeting customer demands, accurately and on time, with acceptable costs. As the OP process can contribute up to 50 % to the overall warehouse operational costs, design of the order picking system (OPS) needs special attention during the warehouse design process. In existing systems, the need for improvement is often caused by the change in demands. This paper analyses the possibilities of low-level picker-to-part OPS improvement through appropriate decision making on different design levels: tactical and operational. In this paper, a simulation-analytical model is developed to evaluate different OPS scenarios based on three storage assignment policies, four routing strategies and two different OP methods. Two layout variants and the evaluation of the required workforce are considered as well. The experiment results indicate that the application of the proposed model could lead to significant improvements regarding OPS performances and resource utilization.

No abstract

Examination of cadmium (Cd) toxicity and disulfiram (DSF) effect on liver was focused on oxidative stress (OS), bioelements status, morphological and functional changes. Male Wistar rats were intraperitoneally treated with 1 mg CdCl2/kg BW/day; orally with 178.5 mg DSF/kg BW/day for 1, 3, 10 and 21 days; and co-exposed from 22nd to 42nd day. The co-exposure nearly restored previously suppressed total superoxide dismutase (SOD), catalase (CAT) and increased glutathione peroxidase (GPx) activities; increased previously reduced glutathione reductase (GR) and total glutathione-S-transferase (GST) activities; reduced previously increased superoxide anion radical (O2 ·−) and malondialdehyde (MDA) levels; increased zinc (Zn) and iron (Fe), and decreased copper (Cu) (yet above control value), while magnesium (Mg) was not affected; and decreased serum alanine aminotransferases (ALT) levels. Histopathological examination showed signs of inflammation process as previously demonstrated by exposure to Cd. Overall, we ascertained partial liver redox status improvement, compared with the formerly Cd-induced impact.