Burning mouth syndrome (BMS) is an intraoral burning sensation for which no medical or dental cause can be found. Recent studies suggest that primary neuropathic dysfunction might be involved in the pathogenesis of BMS. Calcitonin gene-related peptide (CGRP) plays an important role in the development of pain and serves as a biological marker of trigeminovascular activation. The aim of this study was to determine the levels of CGRP in the saliva of BMS patients and estimate the trigeminovascular activation in BMS. CGRP levels were measured, by RIA method in 78 BMS patients and 16 healthy subjects. The levels of CGRP were non-significantly decreased in BMS patients in comparison to healthy subjects. These results suggest that trigeminal nerve degeneration may be the underlying cause of BMS.

Identification of new molecular biomarkers could potentially contribute to determination of individuals with OLP predisposition.

HMGB1 polymorphism 1177G/C could be associated with tumor progression and recurrence-free survival in patients with OSCC. The haplotypes of HMGB1 gene might be associated with susceptibility to OSCC and OLP progression to OSCC.

Our trial results indicate that fluoxetine therapy not only improves the psychological status of participants with BMS but also fluoxetine decreases the intensity of pain in these patients.

Traffic safety is one of the key issues nowadays, given the fact that a large number of people lose their lives in traffic accidents every day. There are various influential factors in the occurrence of traffic accidents, the number of vehicles being one of them. This paper assesses the traffic safety in Montenegro in the period 1998-2020 by applying the multiphase modeling with a purpose to obtain comparative results which enable implementation of adequate strategies. A total of six scenarios were formed with two inputs and two outputs in a DEA (Data Envelopment Analysis) model, with the number of registered vehicles per year being an input in all scenarios. In addition, as inputs, the scenarios included AADT (Annual Average Daily Traffic), passengers in road transport, passenger-km by road transport, goods transported by road, tone-km by road, and passengers in local transport. The number of traffic accidents with casualties, the number of traffic accidents with material damage, the number of fatal cases and the number of injured persons, depending on a scenario, were observed as outputs. After the DEA model, IMF SWARA (Improved Fuzzy Stepwise Weight Assessment Ratio Analysis) was applied to determine the weights of inputs and outputs, while the final state of traffic safety by years was determined using the MARCOS (Measurement of alternatives and ranking according to COmpromise solution) method.