Synthesis of nano-oxides in an easy and environmentally friendly way using simple and green materials is one of the hot interests of sustainable chemistry for lots of pharmaceutical and medical applications. Herein, we synthesized α-Fe2O3 nanoparticles (α-Fe2O3 NPs) using ginger extract after that calcination at 400 C° for 4 h. The prepared α-Fe2O3 nanoparticles were examined using ultraviolet-visible reflection spectroscopy (UV-VIS), Fourier Transform Infrared Spectroscopy (FTIR), photoluminescence spectroscopy (PL), X-ray diffraction (XRD), field emission scanning microscopy (FE-SEM), energy-dispersive X-ray (EDX) spectroscopy, and zeta potential. After well characterizations, the potency of the prepared α-Fe2O3 nanoparticles to monitor some scavenging activity was explored against DPPH. Results revealed that PL intensity has one peak in the UV region between (480-490) nm of the spectrum depending on the geometric shape and size of the α-Fe2O3 NPS. The UV-visible spectra showed a peak at 296.0 nm, which represented the α-Fe2O3 NPs. The EDX micrograph confirmed pure oxide and the XRD pattern showed that the α-Fe2O3 NPs had an average crystal size (19.3) nm. SEM images of α-Fe2O3 NPs revealed spherical, rod, and irregular shapes and sizes ranging from (15 to 60) nm. Moreover, the antioxidant activity of α-Fe2O3 NPs against DPPH showed 51.8% free radical scavenging ability at 360 μg/mL, which approved good evidence of the antioxidant activity of α-Fe2O3 NPs.