The interleukin 1 family plays an important role in the immune and inflammatory responses. Coronary artery disease (CAD) is a chronic inflammatory disease. However, the genetic association between IL-37, the seventh member of the IL-1 family, and CAD is unknown. Here we show that a single nucleotide polymorphism in the IL-37 gene (rs3811047) confers a significant risk of CAD. We have performed an association analysis between rs3811047 and CAD in two independent populations with 2,501 patients and 3,116 controls from China. Quantitative RT-PCR analysis has been performed to determine if the IL-37 expression level is influenced by rs3811047. We show that the minor allele A of rs3811047 is significantly associated with CAD in two independent populations under a recessive model (Padj = 5.51 × 10−3/OR = 1.56 in the GeneID Northernern population and Padj = 1.23 × 10−3/OR = 1.45 in the GeneID Central population). The association became more significant in the combined population (Padj = 9.70 × 10−6/OR = 1.47). Moreover, the association remains significant in a CAD case control population matched for age and sex. Allele A of rs3811047 shows significant association with a decreased mRNA expression level of IL-37 (n = 168, P = 3.78 × 10−4). These data suggest that IL37 is a new susceptibility gene for CAD, which provides a potential target for the prevention and treatment of CAD.

This study demonstrates that rs3134069 in TNFRSF11B increases risk of ischemic stroke by decreasing TNFRSF11B expression.

In this study the obstruction of coronary ostium (CO) is unusual but lethal complication under TAVI procedure it is not normally accepted that a range distance between coronary ostium (CO) and the annulus lower than 10mm or in case of sinus of Valsalva diameter around 30mm, while the existing of bulky counted as a leaflet, this is also in case of the valve in valve implantation, in this situation consider as a risks for coronary occlusion (CO) as for TAVI methodology [1,2]. In TAVAI device using J-Valve™ system is a brand new second-generation and TAVI device divided into three U-shapes anatomically oriented devices such as "claspers" which could favor conjectural and "self-positioning" valve implantation [3]. Furthermore, Due to the ability to the enclosure and snaffle the