<p class="abstract"><strong>Background:</strong> The incidence of usage of over-the-counter drugs is drastically increasing day by day. Over-the-counter (OTC) drugs are medicines sold directly to consumer without a prescription from health care personnel. In many countries, OTC drugs are selected by a regulatory agency to ensure that they are safe and effective when used without physician’s care. Taking OTC medicines still has risk. Some interact with other medicines, supplements, food and drinks and some causes problem for people with certain medical conditions.</p><p class="abstract"><strong>Methods:</strong> A descriptive cross sectional was conducted from 1st February - 15th August 2016 among 110 among adults of age group 20 and above residing in Chapapani-12, Pokhara. A pre-tested structured questionnaire were used and data were analyzed using Statistical Package for Social Science (SPSS) for windows version 18.0. Frequency, percentage, chi-square and correlation were performed.  </p><p class="abstract"><strong>Results:</strong> Nearly 1/3^rd of the respondents (33.6%) were of age group 20-29 years and more than half (60.9%) were female. More than half of the respondents (54%) had good knowledge and less than half (47%) had good practice of OTC. There was significant association of knowledge with age, marital status, education and monthly family income. There was significant association of practice with education of respondents. There was weak positive correlation between knowledge and practice (r =0.211).</p><strong>Conclusions:</strong> This showed that the knowledge hadn’t been fully practiced into action by the community people and still they are lacking the concept of over-the-counter drugs and its safe use in daily living.