In orthopedic surgery, a high tibial osteotomy (HTO) is a common treatment. Indications, patient selection, pre-operative planning, surgical procedure, fixation methods, and complications are all covered in detail. This research concentrated on the factors that should be examined in order to produce positive long-term results. To examine the stated hypothesis “medium- to long-term outcomes of high tibial osteotomy and therapies for cartilage healing”. A thorough search of the database like MEDLINE was done. A clinical outcome investigation employing HTO as the main technique, the usage of a sort of cartilage repair, & a minimum follow-up period of 2 years were all necessary. Everything from the research layout to the patient demographics to the sorts of procedures conducted, the clinical consequences to eventual overall knee arthroplasty progression and consequences was investigated in depth. As a result of a combination of HTO and cartilage regeneration procedures, patients may avoid or delay knee arthroplasty surgery in the medium to long term.