We aimed to analyze the expression profile of ACE2 and similar genes with ACE2, predict the number of variations in ACE2, detect the suspected SNPs on ACE2 gene, and perform the pathway analysis of renin-angiotensin system (RAS) and protein absorption-digestion. Moreover, we have predicted the generelated diseases with ACE2. STRING was used to analyze functionally similar genes with ACE2. Exome Variant Server, SIFT, Polyphen2 were used to predict the number of variations in ACE2 and detect the suspected SNPs on ACE2. KEGG database and STRING were used to draw pathway of ACE2. Then, DISEASES resource, FitSNPs, UniProt, BioXpress, IGV Browser, Ensembl Genome Browser, and HIGHLIGHTS  ACE2 is also expressed in testis, heart, thyroid, colon, esophagus, breast, pancreas, lung, liver.  Under expression of ACE2 can cause prostate cancer and head and neck cancer.  ACE2 is over-expressed in the small intestine.  Suggesting that over expression of ACE2 in small intesine can cause symptoms of in COVID-19. 2 Kalkanli Tas, S.; et al.

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