Aim: This study was conducted to determine the dermatological and kidney disease quality of life of patients with uremic pruritus receiving hemodialysis treatment. Material and Methods: The present study was a descriptive comparative study. The sample comprised 200 HD patients. The participants were required to complete a patient information form, 5-D-Itching scale, Dermatological Quality Of Life Index (DLQI), and Kidney Disease Quality Of Life Form (KDQOL-36) used to collect the data of the study. Results: It was determined that the DLQI score average of the patients with pruritus was 11.57±4.74 and that the dermatological quality of life of 60.6% of the patients was affected. It was revealed that the average KDQOL-36 score of the patients with pruritus was 59.36±12.27, and their kidney disease quality of life was of moderate level. Pruritus severity explained a moderate amount of the variability of DLQL (crude R2 =.181) and KDQOL-36 (crude R2 =.184). Conclusion: It was determined that as the severity of uremic pruritus increased, DLQI and KDQO-36 decreased. Therefore, timely treatment, nursing care, and counseling are recommended to monitor the level of pruritus, dermatological and general quality of life to improve the quality of life in HD patients.