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Stem cells have an important role in cell biology, allowing tissues to be renewed by freshly created cells throughout their lifetime. The specific micro-environment of stem cells is called stem cell niche; this environment influences the development of stem cells from quiescence through stages of differentiation. Recent advance researches have improved the understanding of the cellular and molecular components of the micro-environment--or niche--that regulates stem cells. We point out an important trend to the study of niche activity in breast cancers. Breast cancer has long been known to conserve a heterogeneous population of cells. While the majority of cells that make up tumors are destined to differentiate and eventually stop dividing, only minority populations of cells, termed cancer stem cell, possess extensive self renewal capability. These cancer stem cells possess characteristics of both stem cells and cancer cells. Breast cancer stem cells reversal to breast somatic stem cells offer a new therapy, that not only can stop the spread of breast cancer cells, but also can differentiate breast cancer stem cells into normal breast somatic stem cells. These can replace damaged breast tissue. Nevertheless, the complexity of realizing this therapy approach needs further research.

Health problems often occur in the elderly, which affect social interactions. This condition can be one of the triggers for depression in the elderly in the nursing home. The incidence of depression experienced by the elderly who live in the study location is 50-75% due to loneliness, hopelessness, loss of a spouse, and loss of social roles. This type of research is a quantitative non-experimental, correlational research design with a cross-sectional approach. A total of 75 respondents at the Panti Sosial Tresna Werdha Budi Sejahtera, Banjarbaru, South Kalimantan, were taken by purposive sampling technique, and in this study, a questionnaire was used as a research instrument. The statistical test used the Spearman Rank Correlation at a significant level of 0.05 and the results showed that 32 respondents had sufficient social interaction and 32 respondents had a moderate depression level. The results of statistical tests using the Spearman Rank correlation obtained the Correlation Coefficient value of 0.580 and a p-value of 0.000.

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