Objectives In this study, we aimed to investigate the effects of oral administration of Myrmeleon formicarius (antlion) extract on liver and kidney histology in streptozotocin-induced diabetic mice. Methods Twenty-four mice received a single intraperitoneal injection of streptozotocin and were then divided into six groups. Untreated diabetic mice served as the negative control group, and glibenclamide-treated mice served as the positive control group. Mice in the other four groups, namely T1, T2, T3, and T4 groups, received M. formicarius (antlion) extract at 2.5, 5, 7.5, and 10 mg/kg, respectively. Permanent thin sections were used to examine liver and kidney histology. Results The most appropriate antihyperglycaemic dosage of the M. formicarius extract was 10 mg/kg for 2 days. Histological examination of the liver and kidneys showed that the antlion extract at 10 and 5 mg/kg exhibited significant tissue-repair effects. Conclusion M. formicarius (antlion) extract can not only reduce blood glucose levels but also repair hyperglycaemia-induced tissue damage.
Daun tembakau sebagian besar digunakansebagai bahan baku rokok saat ini oleh industri rokok, walaupun rokok dianggap kurang baik dari sisi kesehatan. Sementara daun tembakau jarang digunakan untuk bidang pangan dan kesehatan. Dalam penelitian ini, daun tembakau digunakan sebagai sumber minyak atsiri yang selanjutnya berfungsi sebagai senyawa antimikroba. Minyak atsiri didapatkan dengan cara destilasi uap daun tembakau kering, dan senyawa dalam minyak atsiri selanjutnya dideteksi dengan gas kromatografi mass spektra (GC-MS) sebelum diuji kemampuannya dalam menghambat pertumbuhan Candida albicans. Hasil uji menunjukkan kadar air daun tembakau sebesar 79,67+1,29%, sedangkan rendemen dan berat jenis minyak atsiri daun tembakau sebesar 0,026+0,004% dan 0,934+0,169 g/ml. Komponen kimia minyak atsiri daun tembakau terdiri dari 39 komponen dengan 16 senyawa komponen utama antara lain asam 7-Octadecanoic, methyl ester (CAS) dan neophytadiene. Aktivitas antimikroba minyak atsiri daun tembakau akan semakin tinggi dengan meningkatnya konsentrasi minyak atsiri, dengan zona hambat 7,222 mm pada konsentrasi 72% (v/v). Konsentrasi minyak atsiri daun tembakau yang dapat menghambat pertumbuhan C. albicans sebesar 3,67 mg/ ml - 29,18 mg/ml.
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