Along with the development of the internet, the need for data security is increasing. Ensuring the security of data requires special ways. Among these are cryptography and steganography. Because of the need for this method, many new data security methods have emerged. One of them is using DNA media. DNA cryptography and steganography utilize the properties of DNA to secure and hide secret messages. This paper proposes a combined method between the Playfair cipher cryptographic technique and the DNA substitution steganography algorithm for data security. Comparative analysis was conducted on techniques that are being tested by using similar methods. Four tests are conducted to measure the performance of the proposed method and another method was tested for comparative purposes. Four tests that were conducted are hiding capacity and key length test, speed test, endurance test, and steganalysis test. The result shows that the hiding capacity and key length test is better than other techniques. Steganalysis test result is also better than other tested techniques. Furthermore, in the speed test and endurance test, the results are quite satisfactory, not far from the others technique that is tested. The proposed method had a better performance than any other method that get tested, especially in speed performance and endurance performance.

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