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Aim. Demonstration of three clinical cases of immune thrombocytopenic purpura (ITP) that developed during the pandemic of a novel coronavirus infection (COVID-19) from the personal practice of the authors.Materials and methods. A brief review of the literature on the diagnosis and differential diagnosis of COVID-19-associated ITP is presented. Three clinical observations of this pathology are given.Results. In two situations, thrombocytopenia developed after severe COVID-19-associated pneumonia. In one case, ITP was diagnosed after a viral infection; PCR test for COVID19 was negative. A young patient without comorbidities with severe thrombocytopenia and hemorrhagic syndrome was treated with glucocorticoids and thrombopoietin receptor agonists (TPO-RAs). After achieving remission, glucocorticoids were first discontinued, and then TPO-RAs. In elderly patients with a serious comorbid pathology, glucocorticoids were prescribed for a short time, and remission was achieved with TPO-RAs.Conclusion. The choice of therapy for ITP that developed during the COVID-19 pandemic depends on the clinical situation, the presence or absence of COVID-19 infection, the patient’s somatic status, and the presence of comorbid pathology. TPO-RAs play an important role in the treatment of ITP, including those associated with COVID-19.

Aim. Demonstration of cases of melanoma of rare localization – with damage to the respiratory system.   Materials and methods. A brief review of the literature on non-skin melanomas is presented; special attention is paid to melanomas of airways and lungs, primary localization and metastatic lesions. Clinical observations of this pathology are given.   Results. The paper presents two rare cases from the personal practice of the authors: the diagnosis of primary melanoma of the paranasal sinuses with germination of the base of the skull and metastatic lung damage, in which it was difficult to determine the primary localization of the tumor. In both cases, differential diagnosis was carried out with other formations in the respective areas. The final diagnosis was made by histological and immunohistochemical studies.   Conclusion. The diagnosis of melanoma with damage to the respiratory organs requires differential diagnosis with other formations of this localization. A histological and immunohistochemical study helps to establish the final diagnosis.