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Reactions of p-Nitrophenyloxirane with Amines Containing Fragments withBicyclic Skeleton. -Reaction of p-nitrophenyloxirane (I) with several amines containing norbornane-or norbornene-bearing substituents (II) provides access to the corresponding p-nitrophenyl-substituted ethanolamines (III). Compound (IIIe) is obtained as a mixture of two diastereomers and this is proposed to result from steric hindrance at the tertiary nitrogen atom. Acylation and sulfonylation of some of the novel amino alcohols is carried out to furnish amides or sulfonamides, resp., in good yields. A screening of the biological activity of compound (IIIa) reveals that it possesses analgesic, anticonvulsant, tranquilizing and antiphlogistic activity and is more active than the parent amine (IIa). -(KAS'YAN, A. O.; GOLODAEVA, E. A.; TSYGANKOV, A. V.; KAS'YAN, L. I.; Russ.

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