In order to identify unwanted adverse reactions (ADRs) to antituberculosis drugs, using original questionnaires, a voluntary questionnaire was conducted among 40 patients with respiratory tuberculosis and 42 patients with HIV-infection and tuberculosis concomitant pathology. In both groups, most patients were treated according to IV and V chemotherapy regimens, in the group of patients with TOD – 72.5% and in the group of patients with HIV/TB – 71.4%. A total of 965 undesirable side reactions were recorded; the minimum number of undesirable side reactions in one patient is 0, the maximum is 40. In patients in the TOD group, the most frequently observed ADRs were from the central nervous system and sensory organs, the gastrointestinal tract and the musculoskeletal system. In patients in the HIV/TB group, ADRs of the central nervous system and sensory organs, the gastrointestinal tract and the immune system prevailed. In the group of patients with TOD, adverse reactions with a moderate degree of severity were most often noted, in the group of patients with HIV/TB – with a mild degree of severity. According to the severity of ADRs, significant differences were established only when comparing the total number of reactions in both groups of patients

The objective: to study the long-term changes (1991-2020) in tuberculosis mortality in population of Altai Kray and assess the impact of certain categories of citizens on the formation of this rate.Subjects and Methods: Statistical Forms no. 8, 30, and 33, statistical compilations, and medical scientific publications.Results. In order to analyze the curves reflecting changes in tuberculosis mortality in Altai Kray and Russia, these curves have been divided into three conventional periods. General trends have been identified but there are some peculiarities: a significant excess of the average longterm value of the rate versus this rate for whole of Russia; this rate increased faster in the conventional period of 1991-2005. Using the statistical method, it has been established that the formation of tuberculosis mortality rate in the population of Altai Kray was influenced by tuberculosis mortality rate in the Federal Penitentiary Service in 1997 and 1998 and in homeless people in 2005-2008.

The article presents the results of analysis of medical histories and roentgenologic archive (rontgenograms, linear tomograms, photofluorograms, multispiral computer tomography data) of 85 patients with tuberculosis of organs of thoracic cavity from one of departments of hospital of anti-tuberculosis dispensary of Barnaul. To specify roentgenologic characteristics of clinical forms of tuberculosis the comparative analysis was implemented concerning description of results of roentgenologic analysis comprised by roentgenologists and authors of article. The hyper-diagnostic of clinical forms “disseminated tuberculosis of lungs” and “infiltrative tuberculosis of lungs” was established. The discrepancy between roentgenologic syndromes and clinical forms of tuberculosis was revealed. The underestimation of significance of emphasis of leading roentgenologic syndrome for formulation of clinical form of tuberculosis is emphasized.