2005 Bridged compounds Q 0060Synthesis and Antiarrhythmic Activity of 5-Amino-exo-3-azatricyclo[5.2.1.0 2,6 ]decan-4-one. -Products (I) show antiarrhythmic activity with ED50 values of 0.28 and 0.33 mg/kg on the aconotine and calcium chloride models. -(GORPINCHENKO, V. A.; YATSYNICH, E. A.; PETROV, D. V.; KARACHURINA, L. T.; KHISAMUTDINOVA, R. Y.; BASCHENKO, N. Z.; DOKICHEV, V. A.; TOMILOV, Y. V.; YUNUSOV, M. S.; NEFEDOV, O. M.; Khim.-Farm. Zh. 39 (2005) 6, 9-11; Inst. Org. Chem., Ufa Res. Cent., Russ. Acad. Sci., Ufa 450054, Russia; Russ., Abstr. Eng.) -Y. Steudel 42-078

Synthetic procedure was developed for preparation of exo-oriented di-and tetraamines of the norbornane series by 1,3-dipolar cycloaddition to norbornene and norbornadiene of generated in situ diazomethane followed by reduction of arising pyrazolines catalyzed by Raney nickel.

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Exo -2-amino-exo-3-aminomethylbicyclo[2.2.1]heptane (I) and 5-amino-exo-3-azatricyclo[5.2.1.0 2,6 ]decan-4-one (II) were synthesized and characterized with respect to antiarrhythmic activity. Compound II exhibited antiarrhythmic activity with ED 50 = 0.28 and 0.33 mg/kg on the aconitine and calcium chloride models of arrhythmia, respectively. Compound I did not show antiarrhythmic activity and exhibited acute toxicity corresponding to LD 50 = 450 mg/kg.

2006 Bridged compounds Q 0060 Synthesis of Amines from Norbornane Series. -The reaction of norbornene and norbornadiene with diazomethane is studied. -(YATSYNICH, E. A.; PETROV, D. V.; DOKICHEV, V. A.; TOMILOV, Y. V.; Russ.