We present a convenient synthesis of novel heteroaryl-fused 3-oxo-1,4-thiazepine-5-carboxamides and 5-oxo-1,4-thiazepine-3-carboxamides using a modification of four-component Ugi condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds and discuss the scope and limitations of the chemistry involved.

The title compounds (I) dimerize in the presence of basic catalysts to form the aminocyclohexadienes (IIa) and (IIb).

One-Step Assembly of Carbamoyl-Substituted Heteroanellated [1,4]Thiazepines. -A convenient route to novel heteroanellated thiazepines is reported. -(ILYN, A. P.; LOSEVA, M. V.; VVEDENSKY, V. Y.; PUTSYKINA, E. B.; TKACHENKO, S. E.; KRAVCHENKO, D. V.; KHVAT, A. V.; KRASAVIN, M. Y.; IVACHTCHENKO*, A.

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