The course of pregnancy and delivery in a patient after Fontan repair of double-outlet right ventricle is herein presented. She uneventfully delivered a healthy infant in good general condition at 38 weeks of gestation through a caesarean section, at 24 years after cardiosurgery. Although the patient demonstrated a good hemodynamic state after the operation and conceived while being clinically stable, a worsening of her general condition was observed. After a 4-year follow-up it was clear that pregnancy and delivery had a harmful effect on her cardiovascular function.

The genetic polymorphism of drug oxidation mediated by cytochrome P450IID6 (CYP2D6) was determined in 154 Polish volunteers using debrisoquine as the test substance. The results showed a bimodal distribution of the debrisoquine metabolic ratio (MR). Nine persons (5.8%) with MR > 12.6 were classified as poor metabolisers (gene frequency 0.242), which is in substantial agreement with the data reported for other Caucasian populations.

Takotsubo cardiomiopathy is a rare, very interesting disease which aetiology stays unclear. It manifests with a typical stenocardia associated with a chronic and acute stress. It affects most commonly white female in a perimenopausal age. Diagnosis is based on a quite fast disappearing typical changes showed in electrocardiography and echocardiography associated with a normal view of coronary arteries in angiography. Prognosis is usually successful.

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