No abstract

ELATION WITH GH SECRETION AFTER TRH ADMINISTRATION. A N D ADOLESCENTS.The frequency of GH elevation observed in subjects with IDDM prompted us to look for pituitary autoantibodies. An indirect immunofluorescence technique utilizing human and guinea pig hypophysis was used to detect their presence in GH, TSII, and prolactin pituitary cells. Studies are now in progress to discriminate these specific endocrine cells autoantibodies. 26 subjects (12 boys, 14 girls, ages 7-20, mean age 12 1 yr) were tested after TRtl administration (7 pg/kg i.v., max. 200 pg). In controls, none had a significant response of plasma Gti as defined by an increase to at least twice the baseline levels and greater than 5 ng/ml. In IDDM children, a significant GH elevation was observed in 17 of 26 cases ( 9 girls, 8 boys) with a mean + SE level of 17.1 + 2.9 ng/ml (range 7.2 -39 ng/ml) (p<0.02 witE normal). Among th; responders to TRH, 14/17 had positive serum pituitary autoantibodies, while in the 9 children with no GH response to TRH, 7/9 had a negative determination. However, it is of interest to note that all patients except one had positive islet-cell antibodies in their serum In conclusion, these results are in agreement with the known paradoxical response of GH after TRH in IDDM patients, but not with the lower incidence reported in adult females. In addition, the study of pituitary autoimmunity could partly explain the changes in GH secretion observed in IDDM patients. Breakdown o f ORB i s reported as o n e o f t h e earliest retinal c h a n g e s i n adult diabetic patients (Cunha-Vaz.lg75). I n t h i s s t u d y w e investigated u h e t h e r vitreous fluorophotometry (VFPT) may permit t h e detection similar c h a n g e s in young patients.T h e permeability o f ORB w a s examined by V F P H i n 3 2 young diabetic patienis (8.4-20 y r s old) a n d i n 1 0 non-diabetic subjects o f same age. A11 patients had normal fundi a n d uere treated uith insulin injection t w i c e a day. V FASTING BLOOD GLUCOSE (BG) LEVELS IN THE LATENT PERIOD (LP) OF IDWM IN CHILDREN.We retrospectively analyzed the occasional fasting BG concentration o f 21 children and OGTT o f 7 subjects who developed IDDM 60-8 months later. Approaching symptomatic diabetes the fastlng BG levels (72-115 mg/dl) progressively increased with a r-value o f 0.68(p 180 mg/dl)and in 3 of them also at 180 min (> 140 mg/dl);glycosuria appeared in 2 subjects.In spite of these abnormalities BG levels were not further controlled before the overt onset o f IDDM. These retrospective data (rarely avalla ble in the PL o f IDDM in children) confirm that the abrupt clinical onset of diabetes may b e preceeded b y a long period of abnormal BG levels and insulin secretor y capacity. We suggest that monitoring of these parameters may constitute an effective and non-expensive mcasure to id...

tinctive marks of androgen insensivity and gonadal dysaenesis.Clinica1 features of both conditions were found in thepre-W e studied BP patterns and the Renin-Angiotensin-Al dosterone axis (RAA) of 9 7 IDDM children (3-15 yrs old) in relation to the auxological data,the metabolic control and duration of diabetes (1-13 yrs).We analysed a total of 712 BP measurements. RESULTS. Mean systolicBP levels for age groups were at the 50th percentile of the general population,while the mean diastolic B P w e r e at the 75th in both sexes.Systolic and diastolic BP levels were directly and significantly related to age, weight,height,Quetelet index,duration of disease and HbA1. Plasma Renin Activity (PRA) levels,all withinnof

Post natal hypoglycemia rclated to I~ypcrl~~sulinism of diabetic womcn l'ctuscs is prcscntly thc rs.1jor compl lcatlon of 11)bI. Tl~c alln of this study was to determine hypcrinsulinism degrec to lead to an appropriate metabolic managcmcnt. ClrcuLating immunoreactive C pcptidc providcs ;I mcans of studying L1 ccLl function of 1 1) ! I bccausc insulin-antibudics cross tlic placrnt;~ ; hut its RIA re

Background Individuation and management of the contacts of confirmed COVID-19 infection cases allows to quickly identify and isolate any secondary cases and interrupt the chain of transmission of the infection. Contact tracing is unquestionably very useful in stemming the spread of the pandemic from SARS-Cov 2 however there are no pediatric data that have measured the effectiveness of this method.MethodsFrom 30 October 2020 to 30 April 2021 ,during the second wave of the Covid pandemic, 19 primary care pediatricians reported suspected cases of SAR Cov 2 to the Public Health Service of the Piacenza district via a digital platform relating to a total pediatric population of about 17,500 children. All reported cases underwent a molecular PCR test as soon as possible and in any case within 48 hours. At the same time Public Hygiene Service implemented contact tracing in the same pediatric population in all children who were in close contact with positive cases .Results On the basis of clinical suspicion 1306 subjects underwent a molecular PCR nose pharyngeal swab for Covid -19, 107 of them tested positive (8,2% of reports-0.6% of the monitored population). In the same period, the Public Hygiene Service, through contact-tracing, identified another 1244 positive subjects in the same population of 17,500 children (7,1% of the monitored population).ConclusionsOur experience confirm that contact tracing is strongly raccomended for the managment of the SAR Cov 2 pandemic .It was about eleven times more sensitive than the clinical criteria for identifying positive subjects in pediatric age, often asymptomatic, during the second wave of the Covid pandemic.