No abstract

In a patient sample predating the widespread use of cholinesterase inhibitors, we found that approximately one fifth of individuals with AD demonstrated periods of prolonged cognitive stability. This significant interindividual variability must be considered when providing prognostic information to families and when assessing individual patient responses to pharmacotherapy. We advise caution when assessing results of potentially disease-modifying agents at the individual patient level.

No abstract

Ab s tractWe describe a global closed orbit feedback experiment, based upon a real time harmonic analysis of both the orbit movement and the correction magnetic fields. The feedback forces the coefficients of a few harmonics near the betatron tune to vanish, and significantly improves the global orbit stability. We present the result of the experiment in the W ring using 4 detectors and 4 trims, in which maximum observed displacement was reduced by a factor of between 3 and 4 .

We are exploring the use of Neural Networks, using the SNI S simulator [I for orbit control in-accelerators (primarily circular accelerators) and storage rings. The orbit of the beam in those machines are measured by orbit monitors (input nodes) and controlled by orbit corrector magnets (output nodes). The physical behavior of an accelerator is changing slowly in time. Thus, an adop tive algorithm is necessary. The goal is to have a trained net which will predict the exact corrector strengths which will minimize a measured orbit. The relationship between "kick" from the correctors and "response" from the monitors is in general non-linear and may slowly change during long-term operation of the machine. In the study, several network architectures are examined as well as various training methods for each architecture. 'Work performed under the auspices of the U.S. Dept. of Energy under contract no. DGACOZ 76CH00016.