Клинические рекомендации ОССН -РКО -РНМОТ . Сердечная недостаточность: хроническая (ХСН) и острая декомпенсированная (ОДСН) . Диагностика, профилактика и лечение Мареев В . Ю . 1 (сопредседатель рабочей группы), Фомин И . В . 2 (сопредседатель рабочей группы), Агеев Ф .

Comparing lipid levels and hemostatic variables as a function of glycosylated hemoglobin level, we conclude that diabetes control has greater influence on these parameters than the type and dose of steroids involved in the contraceptive devices.

Homocysteine, a sulfur-containing amino acid formed during the metabolism of methionine, exert cytotoxic effects on vascular endothelium. Molecular mechanisms of homocysteine-induced cellular dysfunction include increased inflammatory cytokine expression, altered nitric oxide bioavailability, induction of oxidative stress, activation of apoptosis and defective methylation. Hyperhomocysteinemia is associated with an increased risk of atherosclerotic and thromboembolic disorders, as well as hyperinsulinemia and may partially account for increased risk of cardiovascular disease associated with insulin resistance. Women with PCOS are more likely to develop components of the metabolic syndrome such as disturbances of carbohydrate metabolism, obesity, hypertension and dyslipidemia, which in turn are risk factors for cardiovascular disease. A number of studies confirmed the presence of increased serum homocysteine concentration in PCOS patients and the possible determinants of this observation are still debated. PCOS treatment options can influence homocysteine levels.

Aim. Current study aimed to adapt and evaluate the psychometric properties of Russian versions of Patient Health Questionnaires 2 and 9 (PHQ-2 and PHQ-9) used for detection of depression in general medical practice worldwide.Material and methods. Questionnaires were translated into Russian and adapted with regard to linguistic features of population. A study was performed on a sample of 193 patients (130 female, 63 male, mean age 34,6±11,4), who attended general practitioners in outpatient practice department of NRC for Preventive Medicine. Patients filled in PHQ-2 and –9 questionnaires in presence of clinical psychologist and then assessed for depression by a psychiatrist (using ICD-10 criteria).Results. The optimal measures of sensitivity and specificity corresponded to cut-off scores of 3 for PHQ-2 (66,2% and 87,4% respectively) and 10 for PHQ-9 (68,9% and 93,3% respectively). Russian questionnaires were found to success in sensitivity, specificity and their positive predictive values are comparable to similar research data reported in literature. Article discusses the principles of implementation of the studied scales for depression screening in general medical practice.

The releasing system 'NuvaRing' proved to be a reliable and safe means of contraception for late reproductive age women with type 1 DM.