In diphtheria, the extent of hypermyoglobinaemia (> 2000 ng/ml) and an increased LDH1/LDH2 (> 1) ratio are reliable markers for the development of carditis indicating a poor prognosis.

Background. To estimate the efficiency of special child pre-school institution (SCPI) in prophylaxis of allergic diseases in children. Methods. 84 children with allergies aged between 10 months and 4 years old were observed. Among them 56 attended the SCPI and 28 (comparative group) attended the basic CPI. All children were passing through clinical, allergological, immunological examination as well as physical and mental development observation. Results. In this research the risks of development of allergies were thoroughly analyzed as well as the results of observation and check-ups of children with allergic diseases who attended to specialized SCPI or basic CPI. In the SCPI dietary conditions were kept, the hypo allergic diet was introduced into practice, the food allowance was balanced in protein, fat, carbohydrates and calorie contents due to physiological needs by substitution of foodstuffs. In the basic CPI these conditions weren't provide. In the SCPIs systematic observation of children is established and the cooperation of parents and doctor in charge of the case allows carrying out continuous pathogenetic therapy. Medical and prophylactic measures decrease the number of allergies' exacerbations and allow parents to proceed their usual activities, also improve the life conditions of children and their parents. Conclusion. The effectiveness of improving of health on the basis of SCPI is approximately 84,5% and the same in basic CPI is 66,75%. The research proposes the method of calculation of needs in SCPI and can be used in the organization of SCPI for children with allergic pathologies.